A new publication for the Acta Materia Medica journal highlights the versatile biological activities of isosteviol and its derivatives. These diterpene compounds exhibit a broad range of effects, including antiviral, antibacterial, antioxidant, antitumor, analgesic, anti-inflammatory, antipyretic, antifungal, and anticardiovascular disease properties.
Due to its distinct diterpene structure, isosteviol is commonly utilized as a core framework in drug development. This allows medicinal chemists to create highly selective, potentially active, and multifunctional isosteviol analogs for the treatment of various diseases. Recent advancements in the design and synthesis of isosteviol derivatives have proven to be highly effective and significant in the field of medicinal chemistry.
This review article provides an overview of the novel derivatives derived from the structural modification of isosteviol, emphasizing their pharmacological activities. It aims to offer valuable insights for developing new synthetic strategies, creating innovative isosteviol derivatives, and guiding preclinical studies for the development of drugs with enhanced pharmacological effectiveness.